Correlation between oxidative stress and Hydroxyproline content in Liver Fibrosis

Background & Objectives: Hepatic fibrosis is the extreme extracellular matrix buildup of collagen due to chronic liver disorders. Progressive results in cirrhosis and hepatic failure. Nilotinib considered a 2nd generation tyrosine kinase inhibitor, which exhibited antifibrotic efficacy. Stem cells release cytokines growth factors paracrine-mediated anti-inflammatory effects vitro vivo. Hence, stem conditioned medium (SC-CM) may have an role. This study designed explain association between oxidative stress markers hydroxyproline content fibrosis. Methods: Sixty male wistar rats were distributed into six major groups; control group, CCl4 Free media (CCl4 Nilotinib) exosomes) group. They had intraperitoneal injection with for nine weeks treatments Nilotinib, cell exosomes (extracted from Liver mesenchymal cells), combined treatment 5th week 9th intoxication. Oxidative parameters (e.g. MDA, SOD, GSH, CAT, NO, NOS) estimated each Results: showed significant positive correlation Hydroxyproline NO NOS. Also, there negative SOD CAT. Conclusion: There And